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1. (IN2997/KOLNP/2011) METHOD OF MAKING SMALL LIPOSOMES

Office : India
Application Number: 2997/KOLNP/2011 Application Date: 15.07.2011
Publication Number: 2997/KOLNP/2011 Publication Date: 10.02.2012
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2009068499 ; Publication Number:WO2010078045 Click to see the data
IPC:
A61K 9/127
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants: ONCOTHYREON, INC.
Inventors: DUPUIT, ROBERT, A.
REILLEY, WILLIAM, J.
Priority Data: 61/138,353 17.12.2008 US
Title: (EN) METHOD OF MAKING SMALL LIPOSOMES
Abstract:
(EN) Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture soliposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate ofcooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomesare of a particle size less than about 200 nm.
Also published as:
EP2367532SG172257JP2012512260US20120034294CN102256595CA2747182
EA201100829JP2014224127MX2011006562KR1020110094114CN105935352AU2009333177
AU2013273711BRPI0923001WO/2010/078045