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1. IN1766/KOLNP/2010 - (1H-PYRAZOLO (3,4-B) PYRIDINE-4-YL)-PHENYLE OR -PYRIDIN-2-YLE DERIVATIVES AS PROTEIN KINASE C-THETA

Office
India
Application Number 1766/KOLNP/2010
Application Date 17.05.2010
Publication Number 1766/KOLNP/2010
Publication Date 25.11.2011
Publication Kind A
IPC
C07D 47/04
Applicants VERTEX PHARMA CEUTICALS INCORPORATED
Inventors JIMENEZ, JUAN-MIGUEL
MORTIMORE, MICHAEL
COLLIER, PHILIP
MILLER, ANDREW
YOUNG, STEPHEN
MAK, CHAU
DAVIS, CHRISTOPHER
TWIN, HEATHER
BRENCHLEY, GUY
BOYALL, DEAN
KEILY, SHAZIA
SETTIMO, LUCA
Priority Data 60/984,875 02.11.2007 US
61/044,575 14.04.2008 US
61/100,808 29.09.2008 US
Title
(EN) (1H-PYRAZOLO (3,4-B) PYRIDINE-4-YL)-PHENYLE OR -PYRIDIN-2-YLE DERIVATIVES AS PROTEIN KINASE C-THETA
Abstract
(EN) The present inventionrelates to compounds of formula(I) and (IA) useful as inhibitors ofprotein kinase (1a). The inventionalso provides pharmaceuticallyacceptable compositions comprisingsaid compounds and methods of usingthe compositions in the treatmentof various disease, conditions, ordisorders. The invention also providesprocesses for preparing compoundsof the inventions, (a) : in particularprotein kinase C theta, wherein A andA' are independently -N- or -C(R+)-. Ring B is five- or six-memberedsaturated carbocyclic or heterocyclicR1, R2, R3, R4, R5, R6, R7, x and y areas described herein.
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