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1. IN944/MUMNP/2010 - HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES

Office
India
Application Number 944/MUMNP/2010
Application Date 07.05.2010
Publication Number 944/MUMNP/2010
Publication Date 17.09.2010
Publication Kind A
IPC
C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
Applicants TECHNOLOGIES INTEGRALE LIMITED
Inventors FILINOVA, ELENA, YU
Priority Data 60/978,536 09.10.2007 US
Title
(EN) HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES
Abstract
(EN) The present invention relates to a method for producing a HIV vaccine, preventing infection with HIV and/or preventing the development of HIV infection in an individual, the present invention provides formation of HIV specific antibodies capable to recognize and bind to substantially all HIV-is forms as an immune response in an individual, which bind to existing in a current epidemiologic cohort HIV-subtypes and mutants selected after antiretroviral therapy. The present invention also relates to HIV-1 peptides / polypeptides / proteins selection with reverse panning technique, LC mass spectrometry identification of HIV-1 env peptides / polypeptides / proteins, gp 120 and its fragment in particular, production of recombinant HIV-1 env peptides in suitable host with necessary glycosylation - L. tarentolae and using sterically stabilized liposomes (SSL) as an adjuvant-carrier for HIV-specific immune boost composition.
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