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1. IN307/KOLNP/2010 - MULTIPLEXED ANALYSES OF TEST SAMPLES

Office
India
Application Number 307/KOLNP/2010
Application Date 25.01.2010
Publication Number 307/KOLNP/2010
Publication Date 21.05.2010
Grant Number 299483
Grant Date 31.07.2018
Publication Kind B
IPC
C12N 15/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants SOMALOGIC, INC.
Inventors SCHNEIDER, DANIEL J.
NIEUWLANDT, DAN
EATON, BRUCE
STANTON, MARTY
GUPTA, SHASHI
KRAEMER, STEPHEN
ZICHI, DOMINIC
GOLD, LARRY
Priority Data 60/950,281 17.07.2007 US
60/950,283 17.07.2007 US
60/950,293 17.07.2007 US
61/031,420 26.02.2008 US
61/051,594 08.05.2008 US
Title
(EN) MULTIPLEXED ANALYSES OF TEST SAMPLES
Abstract
(EN)
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more targetmolecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection andquantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., anaptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety ofnucleic acid technologies, including amplification, to he applied to a broader range of desired targets, especially protein targets. Thedisclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.