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1. IN1140/DELNP/2008 - ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF

Office India
Application Number 1140/DELNP/2008
Application Date 08.02.2008
Publication Number 1140/DELNP/2008
Publication Date 04.07.2008
Grant Number 299479
Grant Date 31.07.2018
Publication Kind B
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 39/395
Applicants BIOGEN MA INC.
Inventors VIOLETTE, SHELIA
KOOPMAN, LOUISE, A.
SIMON, KENNETH, J.
WEINREB, PAUL, H.
VAN VLIJMEN, HERMAN
SALDANHA, JOSE
LUGOVSKOY, ALEXEY, A.
Priority Data 60/697,442 08.07.2005 US
60/773,310 15.02.2006 US
Title
(EN) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF
Abstract
(EN)
The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.