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1. (IN1140/DELNP/2008) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF

Office : India
Application Number: 1140/DELNP/2008 Application Date: 08.02.2008
Publication Number: 1140/DELNP/2008 Publication Date: 04.07.2008
Grant Number: 299479 Grant Date: 31.07.2018
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2006026598 ; Publication Number:PCTUS2006026598 Click to see the data
IPC:
A61K 39/395
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants: BIOGEN MA INC.
Inventors: VIOLETTE, SHELIA
KOOPMAN, LOUISE, A.
SIMON, KENNETH, J.
WEINREB, PAUL, H.
VAN VLIJMEN, HERMAN
SALDANHA, JOSE
LUGOVSKOY, ALEXEY, A.
Priority Data: 60/697,442 08.07.2005 US
60/773,310 15.02.2006 US
Title: (EN) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF
Abstract:
(EN) The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
Also published as:
KR1020080031049BRPI0612778EP1920065EP2447372EP2458012EP2458013
CN101287841CA2614183EA200800278KR1020130042636KR1020140068200AU2006269266
ES2700025WO/2007/008712