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1. IN7900/DELNP/2007 - BIOMARKER FOR SENSITIVITY TO MTOR INHIBITOR THERAPY IN KIDNEY CANCER

Office India
Application Number 7900/DELNP/2007
Application Date 12.10.2007
Publication Number 7900/DELNP/2007
Publication Date 09.11.2007
Publication Kind A
IPC
G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors SAWYERS, CHARLES, L.
THOMAS, GEORGE,V.
Priority Data 60/662,649 17.03.2005 US
Title
(EN) BIOMARKER FOR SENSITIVITY TO MTOR INHIBITOR THERAPY IN KIDNEY CANCER
Abstract
(EN)
The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregulated in pathologies such as cancer and to reagents and kits adapted for performing such methods. For example a correlation between VHL loss and mTOR inhibitor sensitivity in human kidney cancer cells is disclosed, indicating that VHL loss confers autonomous and angiogenic competitive advantages to such cells.