IN3879/DELNP/2007 "IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA"

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India

Application Number 3879/DELNP/2007

Application Date 23.05.2007

Publication Number 3879/DELNP/2007

Publication Date 31.08.2007

Grant Number 301163

Grant Date 19.09.2018

Publication Kind B

IPC

Applicants ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
INSTITUT GUSTAVE-ROUSSY
UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES
UNIVERSITE PARIS-SUD

Inventors VAINCHENKER, WILLIAM
UGO, VALERIE
JAMES, CHLOE
LE COUEDIC, JEAN-PIERRE
CASADEVALL, NICOLE

Priority Data 0411480 27.10.2004 FR

Title

(EN) "IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA"

Abstract

(EN) The invention relates to variant V617F of protein tyrosine Kinase JAK2, said variant being responsible for Polycythemia Vera. The invention also relates to a method for the preliminary diagnosis of erythrocytosis and thrombocytosis, thereby enabling same to be related to myeloproliferative syndromes or the detection of variant JAK2 V617F in said myeloproliferative syndromes, such that they can be reclassified in a new nosological group, and to the identification of specific inhibitors and siRNA.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10	Transferases (2.)
12	transferring phosphorus containing groups, e.g. kinases (2.7)

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10	Transferases (2.)
12	transferring phosphorus containing groups, e.g. kinases (2.7)

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1. IN3879/DELNP/2007 - "IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA"