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1. IN240/CHE/2005 - SYNTHESIS OF 2-DEOXY-2, 2-DI FLUORO-D-RIBO FURANOASE-3, 5 DI(4-METHYL/4-NITRO/4-CHLORO) BENZOATE AND ITS CONVERSION TO GEMICTABINE HYDROCHLORIDE THEREOF

Office India
Application Number 240/CHE/2005
Application Date 10.03.2005
Publication Number 240/CHE/2005
Publication Date 16.03.2007
Publication Kind A
IPC
C07D 30/32
Applicants SMS PHARMACEUTICALS LIMITED
Inventors POTLURI RAMESH BABU
VENKATA SUBRAMANIAN HARIHARAKRISHNAN
BETINI RAMESH
GUNTURU SATYANARAYANA
Title
(EN) SYNTHESIS OF 2-DEOXY-2, 2-DI FLUORO-D-RIBO FURANOASE-3, 5 DI(4-METHYL/4-NITRO/4-CHLORO) BENZOATE AND ITS CONVERSION TO GEMICTABINE HYDROCHLORIDE THEREOF
Abstract
(EN)
The invention describes the synthesis of hereto unpreported 2-deoxy- 2,2-difluoro-D-ribofuranose-3,5-di (aroyl) derivative of formula -Vb1 where is R=CH3,CI,NO2 and its conversion to Gemcitabine HCI of formula -I, an anti cancer product.

Also published as
EP5750180