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1. (IN2115/DEL/1996) METHOD AND PHARMACEUTICAL COMPOSITION FOR REGULATING LIPID CONCENTRATION

Office : India
Application Number: 2115/DEL/1996 Application Date: 26.09.1996
Publication Number: 2115/DEL/1996 Publication Date: 11.03.2005
Publication Kind : A
Applicants: WARNER-LAMBERT COMPANY
Inventors: THOMAS M.A. BOCAN
Priority Data: 60/006,155 02.11.1995 US
Title: (EN) METHOD AND PHARMACEUTICAL COMPOSITION FOR REGULATING LIPID CONCENTRATION
Abstract:
(EN) The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid regulation. The combination of agents results in a greater reduction in plasma VLDL and LDL cholesterol and increases HDL cholesterol than either alone resulting in a less atherogenic lipoportein profile. The combination is useful in the treatment of patients with or at risk of developing ischemic syndromes in order to restore endogenous vascular endothelium-dependent activities.
Also published as:
CZPV1998-1271IS4720NO19981961SK55798KR1020040029459SG53241
IL123902EP0858336US6124309JPH11515025 CN1201389CN1679953
CA2233558EA199800420KR1019990067270NZ319906NZ512484AU1996072539
GEP20001898BWO/1997/016184