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1. IL153680 - APLIDINE DERIVATIVES

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Office
Israel
Application Number 153680
Application Date 26.12.2002
Publication Number 153680
Publication Date 31.05.2012
Publication Kind B
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/0205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0205containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants PHARMA MAR, S.A.
Agents וולף, ברגמן וגולר
Priority Data 0016148.9 30.06.2000 GB
0103750.6 15.02.2001 GB
Title
(EN) APLIDINE DERIVATIVES
(HE) תולדות אפלידין
Abstract
(EN) The present invention relates to synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them.
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