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1. (ID2018/12130) METHOD FOR INACTIVATING XENOANTIGENS IN BIOLOGICAL TISSUES

Office : Indonesia
Application Number: PID201804262 Application Date: 25.11.2016
Publication Number: 2018/12130 Publication Date: 16.11.2018
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2016078898 ; Publication Number:WO2017093147 Click to see the data
IPC:
A61L 27/36
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
Applicants: BIOCOMPATIBILITY INNOVATION SRL
Inventors: NASO, Filippo
GANDAGLIA, Alessandro
Agents: Maulitta Pramulasari
Priority Data: 102015000078236 30.11.2015 IT
Title: (EN) METHOD FOR INACTIVATING XENOANTIGENS IN BIOLOGICAL TISSUES
(ID) METODE UNTUK MENONAKTIFKAN XENOANTIGEN DALAM JARINGAN-JARINGAN BIOLOGIS
Abstract:
(EN)

A method for inactivating xenoantigens in biological tissues, particularly in tissues that can be used to manufacture bioprosthetic substitutes and/or in bioprosthetic substitutes that are already prepared and intended for human or veterinary clinical use. Such method entails the following steps: - providing a solution based on phenolic compounds, polyphenolic compounds or derivatives thereof, for the inactivation of at least part of the xenogeneic epitopes from such tissues; - incubating the samples to be treated in the various solutions based on phenols/polyphenols in controlled conditions; - subjecting the treated tissues to a series of washes.


(ID)

Suatu metode untuk menonaktifkan xenoantigen dalam jaringan-jaringan biologis, secara khusus dalam jaringan-jaringan yang bisa digunakan untuk membuat substitusi-substitusi bioprosterik dan/atau dalam substitusi-substitusi bioprostetik yang telah dibuat dan dimaksudkan untuk penggunaan klinis manusia dan hewan, yang dicirikan didalamnya bahwa ia mencakup langkah-langkah berikut: - menyediakan suatu larutan yang didasarkan pada senyawa-senyawa fenolik, senyawa-senyawa polifenolik atau derivatif-derivatif darinya, untuk penonaktifan sedikitnya sebagian dari epitop xenogenik dari jaringan-jaringan dimaksud; - menginkubasi sampel-sampel yang akan diperlakukan dalam bermacam larutan berdasarkan pada fenol/polifenol dalam kondisi-kondisi terkontrol; - membuat jaringan-jaringan yang telah diperlakukan tersebut menjalani serangkaian pembersihan.


Also published as:
CA3006234AU2016363536IL259591CN108367098KR1020180090816EP3383446
IN201817021526CU2018000048US20180353647BR112018011021WO/2017/093147