ID2018/10178 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

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Office

Indonesia

Application Number PID201708964

Application Date 13.05.2016

Publication Number 2018/10178

Publication Date 21.09.2018

Publication Kind A

IPC

Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED

Inventors KOTRABASAIAH UJJINAMATADA, Ravi
PANDIT, Chetan

Agents Annisa Am Badar, S.H, LLM

Priority Data 2448/CHE/2015 15.05.2015 IN

Title

(EN) SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

(ID) SENYAWA TETRAHIDROKUINOLIN TERSUBSTITUSI SEBAGAI MODULATOR ROR GAMMA

Abstract

(EN)

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

(ID)

Penemuan ini menyediakan tetrahidroquinolinon tersubstitusi dan senyawa rumus (I) yang terkait, yang secara artifisial berguna sebagai modulator reseptor orfan yang terkait dengan reseptor asam retinoat (ROR), lebih khusus lagi sebagai modulator ROR. Senyawa ini berguna dalam pengobatan dan pencegahan penyakit dan / atau kelainan, khususnya penggunaannya pada penyakit dan / atau gangguan yang dimediasi oleh reseptor ROR. Penemuan ini juga menyediakan pembuatan senyawa dan formulasi farmasi yang terdiri dari paling sedikit satu tetrahidroquinolinon tersubstitusi atau senyawa formula (I) yang terkait, bersama dengan pembawa, pengencer atau eksipien yang dapat diterima secara farmasi.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

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1. ID2018/10178 - SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS