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1. ID2014/02345 - TURUNAN SEFALOSPORIN BARU DAN KOMPOSISI FARMASINYA

Office
Indonesia
Application Number W00201304987
Application Date 29.03.2012
Publication Number 2014/02345
Publication Date 17.07.2014
Publication Kind A
IPC
A61K 31/546
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
545Compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
546containing further heterocyclic rings, e.g. cephalothin
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07D 501/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14Compounds having a nitrogen atom directly attached in position 7
16with a double bond between positions 2 and 3
207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
34with the 7-amino radical acylated by carboxylic acids containing hetero rings
Applicants LEGOCHEM BIOSCIENCES, INC.
Inventors PARK, Tae Kyo
WOO, Sung Ho
KIM, Yong Zu
CHO, Young Lag
CHAE, Sang Eun
LEE, Hyang Sook
YUN, Joung Yul
PARK, Chul Soon
OH, Kyuman
HEO, Hye Jin
KANG, Dae Hyuck
YANG, Young Jae
KWON, Hyun Jin
Agents Drs. J.B. LUMENTA, S.H., L.L.M.
Title
(ID) TURUNAN SEFALOSPORIN BARU DAN KOMPOSISI FARMASINYA
Abstract
(EN) The present invention relates to a novel cephalosporin derivative indicated in chemical formula 1 of the description. In the chemical formula 1, X, Y, L, R1, R2 are identical as defined in the detailed explanation. In addition, the present invention relates an antibiotic medical composition containing the novel cephalosporin derivative of the chemical formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, and a pharmaceutically permitted salt thereof, as active ingredients. The novel cephalosporin derivative of the chemical formula 1, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically permitted salt thereof have a wide antibacterial spectrum for resistant bacteria, have low toxicity, and in particular, show strong antibacterial effect on gram negative bacteria, and is thus useful as an antibiotic.