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1. ID2013/00110 - SENYAWA-SENYAWA PIROLIDINON HETEROAROMATIK TERFUSI

Office
Indonesia
Application Number W00201202917
Application Date 17.12.2010
Publication Number 2013/00110
Publication Date 31.01.2013
Publication Kind A
IPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors Masashi TAKAHASHI
Benjamin JONES
Betty LAM
Zhe NIE
Victoria FEHER
Qing DONG
Christopher SMITH
Yasuyoshi ARIKAWA
Agents TOETI HERATY N. ROOSSENO, DR.
Priority Data 61/289,969 23.12.2009 US
61/386,964 27.09.2010 US
Title
(ID) SENYAWA-SENYAWA PIROLIDINON HETEROAROMATIK TERFUSI
Abstract
(ID)

Diungkapkan senyawa-senyawa dengan formula 1,

,

dan garam-garamnya yang dapat diterima secara farmasi, dimana G, L1, L2, R1, R2, R3, dan R4 adalah ditetapkan dalam spesifikasi ini. Pengungkapan ini juga berhubungan dengan bahan dan metode pembuatan senyawa-senyawa dengan Formula 1, komposisi-komposisi farmasi yang mengandung senyawa-senyawa pirolidinon heteroaromatik terfusi, dan penggunaan senyawa-senyawa tersebut untuk mengobati gangguan-gangguan, penyakit-penyakit, dan kondisi-kondisi yang melibatkan sistem imun dan inflamasi, termasuk artritis reumatoid, keganasan hematologis, kanker-kanker epitel (yaitu karsinoma), dan gangguan-gangguan, penyakit-penyakit, dan kondisi-kondisi lain, dimana penghambat SYK diindikasikan.


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