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1. ID051.4535 - ANTIBODI ANTI-cMET

Office
Indonesia
Application Number W00201102389
Application Date 02.12.2009
Publication Number 051.4535
Publication Date 29.09.2011
Publication Kind A
IPC
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants PIERRE FABRE MEDICAMENT
Inventors WURCH, Thierry
GOETSCH, Liliane
BES, Cedric
Agents Y.T. WIDJOJO, IR.
Priority Data PCT/IB2008/055663 02.12.2008 -
61/184,502 05.06.2009 US
Title
(ID) ANTIBODI ANTI-cMET
Abstract
(ID)

Antibodi yang bisa secara spesifik terikat pada reseptor c-Met manusia dan/atau secara spesifik menginhibisi aktivitas tirosin kinase reseptor tersebut, dengan suatu aktivitas antagonistik yang ditingkatkan, antibodi tersebut terdiri dari suatu suatu region hinge termodifikasi. Suatu komposisi yang terdiri dari suatu antagonis antibodi semacam itu dengan c-Met dan penggunaannya sebagai suatu obat untuk mengobati kanker.


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