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1. GB2594793 - Camellia nitidissima Chi extracted theaflavin medicament for resisting novel coronavirus and preparation method and application thereof

Office
United Kingdom
Application Number 202104084
Application Date 24.03.2021
Publication Number 2594793
Publication Date 10.11.2021
Publication Kind A
IPC
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 36/82
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
82Theaceae (Tea family), e.g. camellia
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A01N 47/44
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
47Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
40the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
42containing —N=CX2 groups, e.g. isothiourea
44Guanidine; Derivatives thereof
A01N 43/16
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
04with one hetero atom
14six-membered rings
16with oxygen as the ring hetero atom
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/785
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
Applicants UNIV SHAOGUAN
Inventors JINSHENG CHENG
WEIHONG WAN
Title
(EN) Camellia nitidissima Chi extracted theaflavin medicament for resisting novel coronavirus and preparation method and application thereof
Abstract
(EN) Novel coronavirus medicament comprising: 20-60 parts theaflavin-3-monogallate extracted from Camellia nitidissima (golden camellia); 20-60 parts theaflavin-3,3’-digallate extracted from Camellia nitidissima; 3-8 parts hyaluronic acid; 8-20 parts nicotinamide; 15-30 parts ceramide; 3-10 parts pyruvate; 12-30 parts sodium pyruvate; 3-8 parts polyhaxemethyleneguanidine; 5-15 parts Tween; 150-500 parts glycerol; and 15-35 parts p-hydroxybenzoic ester. Also disclosed is a method of extracting theaflavins from Camellia nitidissima comprising: washing, drying, crushing, and sieving Camellia nitidissima to obtain powder; adding anhydrous ethyl acetate to extract; evaporating and washing with chloroform and drying (vacuum, 30-80 °C) to obtain crude theaflavin. Theaflavin-3-monogallate and theaflavin-3,3’-digallate are obtained from crude theaflavin by countercurrent chromatography. The medicament is obtained by mixing the extracts with hyaluronic acid, nicotinamide, ceramide, pyruvic acid, sodium pyruvate, polyhexamethylguanidine, Tween, glycerol, and p-hydroxybenzoate to obtain a powder, before ethanol is added and the powder dissolved .The medicament may be a spray.
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