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1. FR2744449 - NOUVELLES PIPERAZINES AROMATIQUES DERIVEES DE CYCLOAZANES SUBSTITUES, AINSI QUE LEUR PROCEDE DE PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION COMME MEDICAMENTS

Office
France
Application Number 9601273
Application Date 02.02.1996
Publication Number 2744449
Publication Date 08.08.1997
Grant Number 2744449
Grant Date 24.04.1998
Publication Kind B1
IPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/495
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
CPC
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
Applicants PF MEDICAMENT
Inventors HALAZY SERGE
JORAND LEBRUN CATHERINE
PAUWELS PETER
CHOPIN PHILIPPE
MARIEN MARC
Priority Data 9601273 02.02.1996 FR
Title
(FR) NOUVELLES PIPERAZINES AROMATIQUES DERIVEES DE CYCLOAZANES SUBSTITUES, AINSI QUE LEUR PROCEDE DE PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION COMME MEDICAMENTS
Abstract
(EN)
Compounds of formula (I), wherein R1 is hydrogen or straight or branched C1-6 alkyl, Z2 is O, NH, CH2O or CH2NH, each of R2 and R3, which are the same or different, is hydrogen or a group selected from straight or branched alkyl, alkoxy, thioether, nitrile, trifluoromethyl or halogen (F, Cl, Br, I), or, when they are adjacent, R2 and R3, taken together, form a 5- or 6-membered ring in order to form, e.g., naphthyl, tetrahydronaphthyl, benzopyrane or benzodioxane, X-Y is NCH2, CH-CH2, C=CH, N or NCH2CH2, and Z1 is -(CH2)n, -(CH2)n CO-, -CO-, -CO(CH2)n-, -SO2-, -SO2(CH2)n-, -O(CH2)n-, -O(CH2)nCO-, -OCO-, -NH(CH2)n-, -NH(CH2)nCO-, -NHCO-, -NHCO(CH2)n-, -NH(CH2)nSO2-, -NHSO2-, -NHSO2(CH2)n-, -CH=CHCO-, -CCCO- -(CH2)nSO2-, -O(CH2)nSO2-.

(FR)

La présente invention concerne les composés de formule (I)
(CF DESSIN DANS BOPI)
dans laquelle:
R1 représente un hydrogène ou un alkyle linéaire ou ramifié comprenant de 1 à 6 atomes de carbone,
Z2 représente O, NH, CH2 O ou CH2 NH,
R2 et R3 identiques ou différents représentent un hydrogène ou un groupe choisi parmi un alkyle linéaire ou ramifié, un alcoxy, thioéther, nitrile, trifluorométhyle ou halogène (F, C1, Br, I), ou, R2 et R3 , lorsqu'ils sont adjacents, pris ensemble, forment un cycle à 5 ou 6 chaînons de façon à constituer par exemple un naphtyle, un tétrahydronaphtyle, un benzopyrane ou un benzodioxane,
X-Y représente NCH2 , CH-CH2 , C=CH, N ou NCH2 CH2 ,
Z1 représente -(CH2 )n -, -(CH2 )n CO-, -CO-, -CO(CH2 )n -, -SO2 -, SO2 (CH2 )n -, -O(CH2 )n -, -O(CH2 )n CO-, -OCO-, -NH(CH2 )n -, NH(CH2 )n CO-, -NHCO-, -NHCO(CH2 )n -, -NH(CH2 )n SO2 -, -NHSO2 -, NHSO2 (CH2 )n -, -CH=CHCO-,-CCCO- -(CH2 )n SO2 -, -O(CH2 )n SO2 -.