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1. FR2811897 - Treatment of diseases associated with peripheral benzodiazepine receptor dysfunction, e.g. peripheral neuropathy, cardiac insufficiency or cancer, using pyridazino(4,5-b)indole-1-acetamide derivatives

Office
France
Application Number 0009655
Application Date 24.07.2000
Publication Number 2811897
Publication Date 25.01.2002
Publication Kind A1
IPC
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants SANOFI SYNTHELABO
Inventors BARTSCH LI REGINE
DUBOIS LAURENT
EVANNO YANNICK
FROISSANT JACQUES
GEORGE PASCAL
MARABOUT BENOIT
MARGUET FRANK
SEVRIN MIREILLE
Priority Data 0009655 24.07.2000 FR
Title
(EN) Treatment of diseases associated with peripheral benzodiazepine receptor dysfunction, e.g. peripheral neuropathy, cardiac insufficiency or cancer, using pyridazino(4,5-b)indole-1-acetamide derivatives
(FR) UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
Abstract
(EN) Use of 7-halo-1-(2-(piperazin-1-yl)-2-oxoethyl)-4-oxo-3-phenyl-3,5-dihydro-4H -pyridazino (4,5-b) indoles (I) for the treatment or prevention of diseases associated with dysfunction of the peripheral benzodiazepine receptors is new. Use of pyridazino-indole derivatives of formula (I) or their acid addition salts is claimed in the preparation of a medicament for the treatment or prevention of diseases associated with dysfunction of the peripheral benzodiazepine receptors. X = halo; Y = H or one or more of halo, OH, Me and OMe; R1 = H or 1-4C alkyl; and R2 = H, 1-4C alkyl, 3-7C cycloalkyl, (3-7C) cycloalkyl-(1-6C) alkyl, phenyl, pyridinyl or phenyl-(1-4C) alkyl.
(FR)

Utilisation d'un compos e, à l' etat de base ou de sel d'addition à un acide, r epondant à la formule g en erale (I) (CF DESSIN DANS BOPI) dans laquelle X repr esente un atome d'halogène, Y repr esente un ou plusieurs atomes ou groupes choisis parmi l'hydrogène, les halogènes et les groupes hydroxy, m ethyle et m ethoxy, R1 repr esente un atome d'hydrogène ou un groupe alkyle, R2 repr esente un atome d'hydrogène, un groupe alkyle, un groupe cycloalkyle, un groupe cycloalkylalkyle, un groupe ph enyle, un groupe pyridinyle ou un groupe ph enylalkyle, pour la pr eparation d'un m edicament destin e à la pr evention ou au traitement d'une maladie li ee au dysfonctionnement des r ecepteurs de type p eriph erique aux benzodiaz epines.


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