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1. ES2330313 - DERIVADOS DE TIOFENO COMO AGENTES ANTIVIRALES CONTRA INFECCION POR FLAVIVIRUS.

Office
Spain
Application Number E02742563
Application Date 11.06.2002
Publication Number 2330313
Publication Date 09.12.2009
Publication Kind T3
IPC
C07D 413/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 333/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
26with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
40Thiophene-2-carboxylic acid
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
A61K 31/341
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/343
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61K 31/426
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants VIROCHEM PHARMA INC.
Inventors CHAN, CHUN, KONG, LAVAL
BEDARD, JEAN
DAS, SANJOY, KUMAR
NGUYEN BA, NGHE
PEREIRA, OSWY, Z.
REDDY, THUMKUNTA, JAGADEESWAR
SIDDIQUI, M., ARSHAD
WANG, WUYI
YANNOPOULOS, CONSTANTIN
Priority Data 2001296731 11.06.2001 US
Title
(ES) DERIVADOS DE TIOFENO COMO AGENTES ANTIVIRALES CONTRA INFECCION POR FLAVIVIRUS.
Abstract
(ES) Un compuesto que tiene la fórmula I:** ver fórmula** o sales farmacéuticamente aceptables del mismo; en la que X es elige entre:** ver fórmula** en la que, M se elige entre: ** ver formula** en las que, R4 es alquilo C1-6; R8 se elige entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-12, aralquilo C6-16; y R15 se elige entre H o alquilo C1-6; J se elige entre:** ver formula** en las que W se elige entre O, S o NR7, en las que R7 se elige entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroarilo C3-12, aralquilo C6-16; y R6 se elige entre H, alquilo C1-12, arilo C6-14 o aralquilo C6-16; Y1 se elige entre un enlace, alquenilo C2-6 o alquinilo C2-6; Y se elige entre COOR16, COCOOR5, P(O)ORaORb, S(O)OR5, S(O)2OR5, tetrazol, CON(R9)CH(R5)COOR5, CON (R9)-SO2-R5 o CONR9OH, en las que cada uno de R9 y R5 se elige independientemente entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, heterociclo C3-12, heteroaralquilo C3-18, aralquilo C6-18; cada uno de Ra y Rb se eligen independientemente entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-18 y aralquilo C6-18; o Ra y Rb se toman junto con los oxígenos para formar un heterociclo de 5 a 10 miembros; R16 se elige entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-18 y aralquilo C6-18; con la condición de que R16 sea distinto de metilo o etilo; R1 se elige entre alquilo C2-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-18 o aralquilo C6-18; R2 se elige entre alquilo C2-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-18 o aralquilo C6-18; R3 se elige entre H, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, arilo C6-14, heterociclo C3-12, heteroaralquilo C3-18 o aralquilo C6-18; Z se elige entre H, halógeno, alquilo C1-6; con la condición de que: cuando X es Benzamida y R1 es fenilo Y1 es un enlace e Y es COOH entonces R3 es distinto de hidrógeno.
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