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1. ES2167710 - TIOFENOPIRIMIDINAS.

Office
Spain
Application Number E97904368
Application Date 30.01.1997
Publication Number 2167710
Publication Date 16.05.2002
Publication Kind T3
IPC
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 5/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
02of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
04for decreasing, blocking or antagonising the activity of the hypothalamic hormones
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants JANSSEN PHARMACEUTICA N.V.
NEUROCRINE BIOSCIENCES, INC.
Inventors CHEN, CHEN
WEBB, THOMAS R.
MCCARTHY, JAMES R.
MORAN, TERENCE J.
Priority Data 9611274 07.02.1996 US
9627689 07.02.1996 US
Title
(ES) TIOFENOPIRIMIDINAS.
Abstract
(ES)
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), INCLUYENDO LOS ESTEREOISOMEROS Y LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE X ES S, SO O SO2; R1 ES NR4 R5 O OR5 ; R2 ES ALQUILO C1-6 , ALQUILOXI C1-6 O ALQUILTIO C16 ; R3 ES HIDROGENO, ALQUILO C1-6, ALQUILSULFONILO C1-6 , ALQUILSULFOXI C1-6 O ALQUILTIO C1-6 ; R4 ES HIDROGENO, ALQUILO C1-6 , MONO- O DI(CICLOALQUIL C3-6 )METILO, CICLOALQUILO C3-6 , ALQUENILO C3-6 , HIDROXIALQUILO C1-6 , ALQUILCARBONILOXI C1-6 AL QUILO C1-6 O ALQUILOXI C1-6 - ALQUILO C1-6 ; R5 ES ALQUILO C1-8 , MONO - O DI (CICLOALQUIL C3-6 ) METILO, AR1 CH2 , ALQUILOXI C1-6 - ALQU ILO C1-6 , HIDROXIALQUILO C1-6 , ALQUENILO C3-6, TIENILMETILO, FURANIL - METILO, ALQUILTIO C1-6 ALQUILO C1-6 , MORFOLINILO, MONO- O DI (ALQUILO C1-6 ) AMINOALQUILO C1-6 , DI(ALQUIL C1-6 ) AMINO, ALQUILCARBON ILO C1-6 ALQUILO C1-6 , ALQUILO C1-6 SUSTITUIDO POR IMIDAZOLILO; O UN RADICAL DE FORMULA: - ALK - O CO - AR1 -; O R4 Y R5 , CONJUNTAMENTE CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS, PUEDEN FORMAR UN GRUPO MORFOLINILO, HOMOPIPERIDINILO, PIPERIDINILO O PIRROLIDINILO, OPCIONALMENTE SUSTITUIDO; AR ES FENILO, FENILO SUSTITUIDO, PIRIDINILO O PIRIDINILO SUSTITUIDO. DICHOS COMPUESTOS MUESTRAN PROPIEDADES ANTAGONISTAS DEL RECEPTOR CRF; SE DESCRIBEN ASIMISMO COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS COMO INGREDIENTES ACTIVOS; METODOS DE TRATAMIENTO DE ALTERACIONES RELACIONADAS CON LA HIPERSECRECION DE CRF, COMO DEPRESION, ANSIEDAD, ABUSO DE SUSTANCIAS, MEDIANTE LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DEL COMPUESTO DE FORMULA (I).