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1. (ES2291268) PROCESO PARA LA PREPARACION DE NUCLEOSIDOS BETA-D-(-)-DIOXOLANO ENANTIOMERICAMENTE PUROS.

Office : Spain
Application Number: E01203571 Application Date: 05.12.1991
Publication Number: 2291268 Publication Date: 01.03.2008
Publication Kind : T3
IPC:
A61K31/505
C07D405/04
A61P31/18
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
CPC:
A61K 31/675
C07D 405/04
Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
EMORY UNIVERSITY
Inventors: CHU, CHUNG K.
SCHINAZI, RAYMOND F.
Priority Data: 07622762 05.12.1990 US
Title: (ES) PROCESO PARA LA PREPARACION DE NUCLEOSIDOS BETA-D-(-)-DIOXOLANO ENANTIOMERICAMENTE PUROS.
Abstract: front page image
(ES) Un proceso para la preparación de un nucleósido enantioméricamente puro Beta-D-[(2Beta,4Beta)-2-(hidroximetil)-4-dioxolanil] a partir de 1,6-anhidromanosa que comprende los siguientes pasos: (i) convertir 1-6-anhidromanosa a su derivado (2,3)-isopropilideno; (ii) preparar (2R,4R) y (2R,4S)-4-acetoxi-2-(oximetil protegido)-dioxolano del derivado (2,3)-isopropilideno; y (iii) condensar el (2R,4R) y (2R,4R)-4-acetoxi-2-(oximetil protegido)-dioxolano del paso (i) con una base heterocíclica en la presencia de SnCl 4, otro ácido Lewis, o triflato trimetilsilil para formar un nucleósido enantioméricamente puro Beta-D-[(2Beta,4Beta)-2-(hydroxymethil)-4-dioxolanil].
Also published as:
EP0562009JP2007008959US5925643JP3421335JPH07502973JP2001097973
CA2099589CA2590125AU1991091259AU1991091475AU1997016640WO/1992/010497