ES2907467 Fragmentos variables insertables de anticuerpos y dominios a1-a2 modificados de ligandos NKG2D

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Spain

Application Number 15864650

Application Date 04.12.2015

Publication Number 2907467

Publication Date 25.04.2022

Publication Kind T3

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Applicants Xyphos Biosciences Inc.

Inventors LANDGRAF, Kyle
STEIGER, Daniel
WILLIAMS, Steven R.
MARTIN, David W.

Agents Pons Ariño Angel

Priority Data 201462088456 P 05.12.2014 US

Title

(ES) Fragmentos variables insertables de anticuerpos y dominios a1-a2 modificados de ligandos NKG2D

Abstract

(ES) Una molécula de dominio α1-α2 que comprende una secuencia de aminoácidos que tiene al menos un 80 % de identidad con SEQ ID NO: 17, en donde dicha molécula de dominio contiene todos de (a)-(c): (a) un resto S en la posición correspondiente a la posición 103 de SEQ ID NO: 17, (b) un resto A, P, S, T o H en la posición correspondiente a la posición 165 de SEQ ID NO: 17; y (c) un resto G en la posición correspondiente a la posición 162 de SEQ ID NO: 17, y en donde dicha molécula de dominio muestra una mayor afinidad de unión a un NKG2D humano en comparación con SEQ ID NO: 17.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02	with ribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04	with deoxyribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
46	from vertebrates
47	from mammals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants
74	Major histocompatibility complex (MHC)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

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1. ES2907467 - Fragmentos variables insertables de anticuerpos y dominios a1-a2 modificados de ligandos NKG2D

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2803	against the immunoglobulin superfamily
2818	against CD28 or CD152

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2851	against the lectin superfamily, e.g. CD23, CD72

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2863	against receptors for growth factors, growth regulators

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
31	multispecific