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1. ES2358923 - PURIFICACION DE MONTELUKAST.

Office Spain
Application Number 06786369
Application Date 05.07.2006
Publication Number 2358923
Publication Date 16.05.2011
Publication Kind T3
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Halogen atoms or nitro radicals
C07D 215/18
CPC
C07D 215/18
Applicants TEVA PHARMACEUTICAL INDUSTRIES, LTD.
Inventors STERIMBAUM, Greta
SHAPIRO, Evgeny
CHEN, Kobi
Agents CURELL CURELL MARCELINO
Priority Data 69700005 05.07.2005 US
Title
(ES) PURIFICACION DE MONTELUKAST.
Abstract
(ES)
Procedimiento para preparar la sal sódica pura de montelukast, que comprende: (a) proporcionar un ácido libre montelukast; (b) convertir el ácido libre montelukast en la sal isopropilamina montelukast; (c) convertir la sal isopropilamina montelukast en la sal di-n-propilamina montelukast; y (d) convertir la sal di-n-propilamina en la sal sódica de montelukast.