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1. ES2699099 - Derivados de tamoxifeno para el tratamiento de enfermedades neoplásicas, especialmente con alto nivel de proteína HER2

Office
Spain
Application Number 14721738
Application Date 07.04.2014
Publication Number 2699099
Publication Date 07.02.2019
Publication Kind T3
IPC
C07F 9/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
54Quaternary phosphonium compounds
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61K 31/662
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
CPC
C07F 9/5442
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P—C bonds
54Quaternary phosphonium compounds
5442Aromatic phosphonium compounds (P-C aromatic linkage)
C07F 9/5449
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P—C bonds
54Quaternary phosphonium compounds
5449Polyphosphonium compounds
C09B 23/0008
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
0008substituted on the polymethine chain
C09B 23/141
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
14Styryl dyes
141Bis styryl dyes containing two radicals C6H5-CH=CH-
C09B 69/001
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
69Dyes not provided for by a single group of this subclass
001Dyes containing an onium group attached to the dye skeleton via a bridge
C09B 69/008
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
69Dyes not provided for by a single group of this subclass
008Dyes containing a substituent, which contains a silicium atom
Applicants Smart Brain s.r.o.
Biotechnologicky ustav AV CR, v.v.i.
Neuzil, Jirí
Springtide Ventures s.r.o.
Inventors


Agents Alvarez Alvarez Sonia
Priority Data 20130308 24.04.2013 CZ
20140066 29.01.2014 CZ
Title
(ES) Derivados de tamoxifeno para el tratamiento de enfermedades neoplásicas, especialmente con alto nivel de proteína HER2
Abstract
(ES) Isómeros E y Z dirigidos mitocondrialmente con una cadena alifática marcada con trifenilfosfonio derivado de tamoxifeno, donde la cadena alifática es alquilo o alquenilo, y sus correspondientes sales de aminas terciarias, seleccionadas de un grupo de sales orgánicas, tales como citrato, acetato, lactato, tartrato, oxalato, ascorbato, mesilato, tosilato o sales inorgánicas como, por ejemplo, sulfato, halogenuro, fosfato y/o su mezclas, los derivados de alquil trifenilfosfonio de tamoxifeno tienen la fórmula general I, **Fórmula** donde n = 8 a 12, y donde Z se selecciona de un grupo de sales orgánicas, tales como citrato, acetato, lactato, tartrato, oxalato, ascorbato, mesilato, tosilato o sales inorgánicas, tales como sulfato, halogenuro o fosfato y en la que el doble enlace cruzado en la fórmula general I, situado en el resto de tamoxifeno, indica que el doble enlace puede tener una configuración E y/o Z y los derivados de alquil trifenilfosfonio de tamoxifeno tienen la fórmula general IA, **Fórmula** donde n = 6 a 10, y donde Z tiene el significado indicado anteriormente y en la que el doble enlace cruzado en la fórmula general IA, situado en la cadena lateral indica que el doble enlace puede tener una configuración E y/o Z.
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