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1. ES2683860 - Compuestos de succinato con permeabilidad celular novedosos

Office
Spain
Application Number 15714820
Application Date 08.04.2015
Publication Number 2683860
Publication Date 28.09.2018
Publication Kind T3
IPC
A61K 31/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
225Polycarboxylic acids
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 323/25
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
24having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
25the carbon skeleton being acyclic and saturated
C07D 281/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 8/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
46containing sulfur
A61K 8/4926
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4906with one nitrogen as the only hetero atom
4926having six membered rings
A61K 8/498
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4973with oxygen as the only hetero atom
498having 6-membered rings or their condensed derivatives, e.g. coumarin
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
C07C 327/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
28having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 327/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
30having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Applicants Neurovive Pharmaceutical AB
Inventors



Agents del Valle del Valle Sonia
Priority Data 201470190 08.04.2014 DK
Title
(ES) Compuestos de succinato con permeabilidad celular novedosos
Abstract
(ES)

Compuesto según la invención que viene dado por la fórmula (I)**Fórmula** o una sal farmacéuticamente aceptable del mismo, en el que el enlace discontinuo entre A y B indica un enlace opcional para formar una estructura cerrada de anillo, y en el que Z se selecciona de -CH2-CH2- o >CH(CH3), A se selecciona de -SR, -OR y NHR, y R es**Fórmula** o B se selecciona de -O-R', -NHR", -SR"' u -OH; y R' se selecciona de las fórmulas (II) a (IX) a continuación: R', R" y R"' son independientemente diferentes o idénticos y se seleccionan de las fórmulas (IV25 VIII) a continuación:**Fórmula** o R1 y R3 son independientemente diferentes o idénticos y se seleccionan de H, Me, Et, propilo, ipropilo, butilo, iso-butilo, t-butilo, O-acilo, O-alquilo, N-acilo, N-alquilo, X-acilo, CH2X-alquilo, CH2Xacilo, F, CH2COOH, CH2CO2-alquilo, X se selecciona de O, NH, NR6, S, R2 se selecciona de Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, C(O)CH3, C(O)CH2C(O)CH3, C(O)CH2CH(OH)CH3, p es un número entero y es 1 ó 2 R6 se selecciona de H, Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, acetilo, acilo, propionilo, benzoílo, o la fórmula (II), o la fórmula (VIII) X5 se selecciona de -H, Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, -COOH, -C(>=O)XR6, CONR1R3 o es la fórmula**Fórmula** X7 se selecciona de R1, -NR1R3, R9 se selecciona de H, Me, Et u O2CCH2CH2COXR8 R10 se selecciona de O-acilo, NH-alquilo, NH-acilo u O2CCH2CH2COX6R8 X6 se selecciona de O, NR8, NR6R8, en los que R6 y R8 son independientemente diferentes o idénticos y se seleccionan de H, alquilo, Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, acetilo, acilo, propionilo, benzoílo, o la fórmula (II), o la fórmula (VIII), R11 y R12 son independientemente diferentes o idénticos y se seleccionan de H, Me, Et, propilo, ipropilo, butilo, iso-butilo, t-butilo, acetilo, propionilo, benzoílo, -CH2X-alquilo, -CH2X-acilo, en los que X es O, NR6 o S, Rc y Rd son independientemente diferentes o idénticos y se seleccionan de CH2X-alquilo, CH2Xacilo, en los que X >= O, NR6 o S, R13, R14 y R15 son independientemente diferentes o idénticos y se seleccionan de H, Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, -COOH, O-acilo, O-alquilo, N-acilo, N-alquilo, X-acilo, CH2X-alquilo; los sustituyentes en R13 y R14 o R13 y R15 pueden unirse en puente para formar un sistema cíclico, Rf, Rg y Rh son independientemente diferentes o idénticos y se seleccionan de X-acilo, -CH2Xalquilo, -CH2X-acilo y R9, alquilo se selecciona de Me, Et, propilo, i-propilo, butilo, iso-butilo, t-butilo, acilo se selecciona de formilo, acetilo, propionilo, isopropionilo, butirilo, terc-butirilo, pentanoílo, benzoílo, acilo y/o alquilo pueden estar opcionalmente sustituidos, y cuando está presente el enlace discontinuo entre A y B, el compuesto según la fórmula (I) es**Fórmula** en la que X4 se selecciona de -COOH, -C(>=O)XR6,**Fórmula** con la condición de que el compuesto no es**Fórmula**