ES2675027 Derivados de 1,2,4-oxadiazol como inmunomoduladores

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Application Number 14790320

Application Date 05.09.2014

Publication Number 2675027

Publication Date 05.07.2018

Publication Kind T3

IPC

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Applicants Aurigene Discovery Technologies Limited

Inventors SASIKUMAR, Pottayil Govindan Nair
RAMACHANDRA, Muralidhara
NAREMADDEPALLI, Seetharamaiah Setty Sudarshan

Agents ELZABURU, S.L.P ELZABURU, S.L.P

Priority Data 4011CH2013 06.09.2013 IN

Title

(ES) Derivados de 1,2,4-oxadiazol como inmunomoduladores

Abstract

(ES) Un compuesto de fórmula (I)**Fórmula** en donde, Q es S o O; R1 representa una cadena lateral del residuo de aminoácido seleccionado de Ser y Thr, opcionalmente sustituido con alquilo o acilo; R2 es hidrógeno o -CO-Aaa; Aaa es un resto de aminoácido seleccionado de Thr o Ser; en donde el extremo C es un extremo libre, amidado o esterificado; R3 representa una cadena lateral de un resto de aminoácido seleccionado de Asn, Asp, Gln y Glu; ----- es un enlace opcional; R4 y R5 son independientemente hidrógeno o están ausentes; R6 es hidrógeno, alquilo o acilo; o una sal farmacéuticamente aceptable de los mismos.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
285	Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01	Five-membered rings
02	Thiadiazoles; Hydrogenated thiadiazoles
04	not condensed with other rings
08	1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245	Oxadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433	Thiadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

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1. ES2675027 - Derivados de 1,2,4-oxadiazol como inmunomoduladores

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10	TECHNICAL SUBJECTS COVERED BY FORMER USPC
S	TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514	Drug, bio-affecting and body treating compositions
885	Immune response affecting drug