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1. (ES2562243) Compuesto neuroprotector eficaz

Office : Spain
Application Number: 06785518 Application Date: 23.06.2006
Publication Number: 2562243 Publication Date: 03.03.2016
Publication Kind : T3
Prior PCT appl.: Application Number:US2006024656 ; Publication Number:2007002512 Click to see the data
IPC:
A61K 48/00
A61K 38/18
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
CPC:
A61K 48/005
A61K 38/1875
Applicants: TISSUEGENE, INC.
Inventors: LEE, Kwan Hee
LEE, Duk Keun
YI, Youngsuk
NOH, Moon Jong
KIM, Hyoung Chun
Agents: Ungría Ungría Javier
Priority Data: 595342 P 23.06.2005 US
Title: (ES) Compuesto neuroprotector eficaz
Abstract: front page image
(EN) The present application discloses a method of preventing degeneration of nerve, which includes: a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; b) transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and c) transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes prevention of degeneration of the nerve.
(FR) L'invention concerne un procédé destiné à la prévention de la dégénérescence des nerfs, procédé comprenant les étapes suivantes : a) génération d'un vecteur viral ou plasmide recombinant comprenant une séquence ADN codant un élément d'une superfamille de croissance transformant ou des protéines d'un facteur neurotrophique liées coopérantes à un promoteur ; b) transfection in vitro d'une population de cellules cultivées avec le vecteur recombinant, conduisant à l'obtention d'une population de cellules cultivées ; et c) transplantation des cellules transfectées en une aire voisine du nerf lésé, de sorte que l'expression de la séquence ADN dans ladite aire voisine du nerf lésé entraîne la prévention de la dégénérescence du nerf.
Also published as:
KR1020080038310KR1020100074340EP1904113JP2009506982CN101232904CA2613551
JP2014088425KR1020130101595KR1020140132010KR1020160021458DK1904113CN106177996
AU2006261889AU2010257453IN10145/DELNP/2007KR1020180057737WO/2007/002512