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1. (ES2492499) Compuestos y composiciones que son inhibidores de la proteína quinasa

Office : Spain
Application Number: 10748211 Application Date: 27.08.2010
Publication Number: 2492499 Publication Date: 09.09.2014
Publication Kind : T3
Prior PCT appl.: Application Number:US2010046930 ; Publication Number:2011025927 Click to see the data
IPC:
C07D 401/14
C07D 403/04
A61K 31/506
A61P 35/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
CPC:
C07D 403/04
A61K 9/0053
A61K 31/4184
A61K 31/506
A61K 45/06
C07D 401/14
C07D 405/14
Applicants: IRM LLC
Novartis AG
Inventors: HUANG, Shenlin
JIN, Xianming
LIU, Zuosheng
POON, Daniel
TELLEW, John
WAN, Yongqin
WANG, Xing
XIE, Yongping
Agents: Vallejo Vallejo Juan Pedro
Priority Data: 238073 P 28.08.2009 US
313039 P 11.03.2010 US
Title: (ES) Compuestos y composiciones que son inhibidores de la proteína quinasa
Abstract:
(EN) The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
(FR) L'invention porte sur une nouvelle classe de composés de la formule 1, sur des compositions pharmaceutiques comportant de tels composés et sur des procédés d'utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, en particulier des maladies ou des troubles qui entraînent une activation anormale de B-Raf.
Also published as:
RSP-2014/0430UAa201203042SG178351IL218084EP2470526DOP2012000051
JP2013503186CN102725283CA2771775EA201200373EP2727918KR1020120062839
TN2012000081NZ598924DK2470526AU2010286569VN30470ID2012/03594
TH140028IN2469/DELNP/2012WO/2011/025927