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1. (ES2410814) Compuestos de tienopirimidina y uso de los mismos

Office : Spain
Application Number: 04705950 Application Date: 28.01.2004
Publication Number: 2410814 Publication Date: 03.07.2013
Publication Kind : T3
Prior PCT appl.: Application Number:JP2004000741 ; Publication Number:2004067535 Click to see the data
IPC:
C07D 495/04
A61K 31/519
A61P 1/04
A61P 5/04
A61P 5/24
A61P 13/08
A61P 15/00
A61P 15/08
A61P 15/18
A61P 17/10
A61P 17/14
A61P 25/28
A61P 35/00
A61P 43/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
04
for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
02
of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
04
for decreasing, blocking or antagonising the activity of the hypothalamic hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
24
of the sex hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
08
of the prostate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
08
for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
18
Feminine contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
10
Anti-acne agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
14
for baldness or alopecia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC:
C07D 495/04
A61K 31/519
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Takeda Pharmaceutical Company Limited
Inventors: CHO, Nobuo
IMADA, Takashi
HITAKA, Takenori
MIWA, Kazuhiro
KUSAKA, Masami
SUZUKI, Nobuhiro
Agents: de Elzaburu de Elzaburu Alberto
Priority Data: 2003020854 29.01.2003 JP
Title: (ES) Compuestos de tienopirimidina y uso de los mismos
Abstract:
(EN) It is intended to provide a compound represented by the following general formula or its salt: wherein R1 represents C1-4 alkyl; R2 represents (1) a nitrogen-containing 5- to 7-membered heterocyclic group optionally having a substituent selected from among (1’) halogeno, (2’) hydroxy, (3’) C1-4 alkyl and (4’) C1-4 alkoxy, (2) phenyl optionally having a substituent selected from among (1’) halogeno, (2’) C1-4 alkoxy-C1-4 alkyl, (3’) mono C1-4 alkyl-carbamoyl-C1-4 alkyl, (4’) C1-4 alkoxy and (5’) mono C1-4 alkylcarbamoyl-C1-4 alkoxy, etc.; R3 represents C1-4 alkyl; R4 represents C1-4 alkoxy, etc.; and n is an integer of from 1 to 4; as a thienopyrimidine compound having antagonism to gonadotropin-releasing hormone.
(FR) L'invention concerne un composé représenté par la formule générale suivante, ou un sel de celui-ci, dans laquelle R1 représente un alkyle C1-4; R2 représente (1) un groupe hétérocyclique de 5 à 7 chaînons contenant de l'azote avec un substituant sélectionné parmi (1') halogéno, (2') hydroxy, (3') un alkyle C1-4 et (4') un alkoxy C1-4, (2) un phényle contenant éventuellement un substituant sélectionné parmi (1') halogéno, (2') un alkyle C1-4 alkoxy C1-4, (3') un mono alkyle C1-4 alkyle-carbamoyle C1-4, (4') un alkoxy C1-4 et (5') un mono alkoxy C1-4 alkyle-carbamoyle C1-4, etc.; R3 représente un alkyle C1-4; R4 représente un alkoxy C1-4, etc.; et n est un entier de 1 à 4. Ce composé est un composé de thiénopyrimidine antagoniste de la gonadolibérine.
Also published as:
NO20053974PL378002PLP.378002MXPA/a/2005/007990KR1020050096171ZA2005/06611
IL169869BRPI0407082CO5590921EP1591446JP2004250439JP2008094846
RU02331648US20060160829US20080108623US20120071486CN1768065CA2514407
US20140221381PT1591446NZ541772DK1591446AU2004207706BNRE/2013/0034
ID047.1556BRPI0407082WO/2004/067535