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1. EP2734537 - POLYPEPTIDE SEPARATION METHODS

Office
European Patent Office
Application Number 12743825
Application Date 20.07.2012
Publication Number 2734537
Publication Date 28.05.2014
Publication Kind A1
IPC
C07K 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
C07K 1/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
02in solution
C07K 1/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
16by chromatography
CPC
C07K 1/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
16by chromatography
22Affinity chromatography or related techniques based upon selective absorption processes
C07K 2317/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
40characterized by post-translational modification
41Glycosylation, sialylation, or fucosylation
C12P 21/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
005Glycopeptides, glycoproteins
G01N 2440/38
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2440Post-translational modifications [PTMs] in chemical analysis of biological material
38addition of carbohydrates, e.g. glycosylation, glycation
Applicants ZEPTEON INC
Inventors BOLTON GLEN REED
BOESCH AUSTIN WAYNE
Designated States
Priority Data 201161509746 20.07.2011 US
Title
(DE) POLYPEPTID-TRENNVERFAHREN
(EN) POLYPEPTIDE SEPARATION METHODS
(FR) PROCÉDÉS DE SÉPARATION DE POLYPEPTIDE
Abstract
(EN)
The present disclosure provides methods and compositions for separating polypeptide glycoforms using a medium that includes an Fc receptor. In certain embodiments, a medium includes an Fc receptor which comprises an extracellular portion of an Fc gamma RIII receptor.

(FR)
La présente invention concerne des procédés et des compositions pour séparer des glycoformes de polypeptide en utilisant un milieu qui comprend un récepteur Fc. Dans certains modes de réalisation, un milieu comprend un récepteur Fc qui comprend une partie extracellulaire d'un récepteur Fc gamma RIII.