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1. (EP2714906) METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA

Application Number: 12725723 Application Date: 01.06.2012
Publication Number: 2714906 Publication Date: 09.04.2014
Publication Kind : A1
Designated States: AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LI,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,RS,SE,SI,SK,SM,TR
Prior PCT appl.: Application Number:EP2012060336 ; Publication Number: Click to see the data
IPC:
C12N 15/113
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants: INST NAT SANTE RECH MED
Inventors: HENRION-CAUDE ALEXANDRA
BANDIERA SIMONETTA
LYONNET STANISLAS
Priority Data: 2012060336 01.06.2012 EP
201161492058 01.06.2011 US
Title: (DE) VERFAHREN ZUR EINSTELLUNG DER EXPRESSION VON MITOCHONDRIALEM GENOM DURCH MICRORNA
(EN) METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA
(FR) PROCÉDÉS POUR L'AJUSTEMENT DE L'EXPRESSION DU GÉNOME MITOCHONDRIAL PAR UN MICROARN
Abstract:
(EN) The present invention relates to a method for adjusting the expression of the mitochondrial genome in a human cell comprising a step consisting of modulating the expression of a least one mi RNA selected from the group consisting of hsa-mi R-1973, hsa-mi R-1275, hsa-mi R-494, hsa-mi R-513a-5p, hsa-mi R-1246, hsa-mi R-328, hsa-mi R-1908, hsa-mi R-1972, hsa-mi R-1974, hsa-mi R-1977, hsa-mi R-638, hsa-mi R-1978 and hsa-mi R-1201.
(FR) La présente invention concerne un procédé d'ajustement de l'expression du génome mitochondrial dans une cellule humaine, comprenant une étape consistant en la modulation de l'expression d'au moins un ARNmi choisi dans le groupe consistant en hsa-mi R-1973, hsa-mi R-1275, hsa-mi R-494, hsa-mi R-513a-5p, hsa-mi R-1246, hsa-mi R-328, hsa-mi R-1908, hsa-mi R-1972, hsa-mi R-1974, hsa-mi R-1977, hsa-mi R-638, hsa-mi R-1978 et hsa-mi R-1201.