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1. EP2648014 - MR imaging using APT contrast enhancement and sampling at multiple echo times

Office
European Patent Office
Application Number 12162970
Application Date 03.04.2012
Publication Number 2648014
Publication Date 09.10.2013
Publication Kind A1
IPC
G01R 33/56
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
CPC
G01R 33/4828
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
4828Resolving the MR signals of different chemical species, e.g. water-fat imaging
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/243
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
24for measuring direction or magnitude of magnetic fields or magnetic flux
243Spatial mapping of the polarizing magnetic field
G01R 33/5605
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
5605by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]
G01R 33/5617
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
561by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
5615Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
5617using RF refocusing, e.g. RARE
Priority Data 12162970 03.04.2012 EP
Title
(DE) MR-Bildgebung mit APT-Kontrastverstärkung
(EN) MR imaging using APT contrast enhancement and sampling at multiple echo times
(FR) Imagerie par RM utilisant une amélioration de contraste APT
Abstract
(EN) The invention relates to a method of CEST or APT MR imaging of at least a portion of a body (10) placed in a main magnetic field B 0 within the examination volume of a MR device. The method of the invention comprises the following steps: a) subjecting the portion of the body (10) to a saturation RF pulse at a saturation frequency offset; b) subjecting the portion of the body (10) to an imaging sequence comprising at least one excitation RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body (10) as spin echo signals; c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; d) reconstructing a MR image from the acquired MR signals. Moreover, the invention relates to a MR device (1) for carrying out the method of the invention and to a computer program to be run on a MR device.