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1. EP2640835 - METHOD FOR THE BIOCATALYTIC CYCLISATION OF TERPENES AND CYCLASE MUTANTS WHICH CAN BE USED IN SAID METHOD

Office European Patent Office
Application Number 11785004
Application Date 17.11.2011
Publication Number 2640835
Publication Date 25.09.2013
Publication Kind B1
IPC
C12N 9/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90Isomerases (5.)
C07C 29/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
56by isomerisation
C12N 15/52
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
CPC
C07C 29/17
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
17by hydrogenation of carbon-to-carbon double or triple bonds
C07C 29/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
56by isomerisation
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C12N 9/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
90Isomerases (5.)
C12P 7/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
Applicants BASF SE
Inventors BREUER MICHAEL
HAUER BERNHARD
JENDROSSEK DIETER
SIEDENBURG GABRIELE
PLEISS JÜRGEN
SIRIM DEMET
RACOLTA SILVIA
Designated States
Priority Data 10191454 17.11.2010 EP
11170812 21.06.2011 EP
11183176 28.09.2011 EP
11785004 17.11.2011 EP
Title
(DE) VERFAHREN ZUR BIOKATALYTISCHEN CYCLISIERUNG VON TERPENEN UND DARIN EINSETZBARE CYCLASE-MUTANTEN
(EN) METHOD FOR THE BIOCATALYTIC CYCLISATION OF TERPENES AND CYCLASE MUTANTS WHICH CAN BE USED IN SAID METHOD
(FR) PROCÉDÉ DE CYCLISATION BIOCATALYTIQUE DE TERPÈNES ET MUTANTS DE CYCLASES POUVANT ÊTRE UTILISÉS DANS CE PROCÉDÉ
Abstract
(DE)
Die vorliegende Erfindung betrifft neuartige Mutanten mit Cyclase-Aktivität und deren Anwendung in einem Verfahren zur biokatalytischen Cyclisierung von Terpenen, wie insbesondere zur Herstellung von Isopulegol durch Cyclisierung von Citronellal; ein Verfahren zur Herstellung von Menthol sowie Verfahren zur biokatalytischen Umsetzung weiterer Verbindungen mit Terpen-ähnlichen Strukturmotiven.

(EN)
The invention relates to novel types of mutants with cyclase-activity and to the use thereof in a method for the biocatalytic cyclisation of terpenes, such as, in particular, for producing isopulegol by the cyclisation of citronellal; to a method for producing menthol and methods for the biocatalytic conversion of other compounds with terpene type structural motifs.

(FR)
La présente invention concerne de nouveaux types de mutants à activité de cyclase et leur utilisation dans un procédé de cyclisation biocatalytique de terpènes, comme en particulier pour la production d'isopulégol par cyclisation de citronellal; un procédé de production de menthol et des procédés de conversion biocatalytique d'autres composants à motifs structuraux de type terpène.