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1. EP2640186 - LEISHMANIA CANINE CHALLENGE MODEL BY SAND FLY BITES

Office European Patent Office
Application Number 11791135
Application Date 15.11.2011
Publication Number 2640186
Publication Date 25.09.2013
Publication Kind B1
IPC
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 39/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
008Leishmania antigens
CPC
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A01K 2227/10
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
A01K 2267/0337
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
0337Animal models for infectious diseases
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection, e.g. against extreme weather
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants MERIAL INC
THE GOVERNMENT OF THE US SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors FISCHER LAURENT BERNARD
KAMAHWI SHADEN
VALENZUELA JESUS
SUAU HAMIDE ASLAN
Designated States
Priority Data 2011060745 15.11.2011 US
41521210 18.11.2010 US
Title
(DE) HUNDEMODELL DER CHALLENGE MIT LEISHMANIA DURCH SANDMÜCKE BISSE
(EN) LEISHMANIA CANINE CHALLENGE MODEL BY SAND FLY BITES
(FR) MODÈLE CANIN DE CHALLENGE AVEC LEISHMANIA PAR PIQÛRES DE PHLEBOTOMES
Abstract
(EN)
The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naive to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.

(FR)
La présente invention concerne un procédé d'infection efficace et reproductible de chiens par Leishmania infantum à l'aide de phlébotomes pour servir de vecteur au parasite. Le procédé de l'invention comporte plusieurs étapes, y compris la vérification que les chiens sont vierges de tout traitement contre la leishmaniose, l'infection des chiens à l'aide de piqûres de phlébotomes infectés par une leishmania, et l'évaluation de la transmission réussie des parasites de la leishmaniose.