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1. (EP2581381) Process for preparing an A2A-adenosine receptor agonist and its polymorphs

Office : European Patent Office
Application Number: 12008201 Application Date: 02.02.2007
Publication Number: 2581381 Publication Date: 17.04.2013
Publication Kind : A3
Designated States: AL,AT,BA,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LI,LT,LU,LV,MC,MK,NL,PL,PT,RO,RS,SE,SI,SK,TR
IPC:
C07H 19/167
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
167
with ribosyl as the saccharide radical
CPC:
C07H 19/16
C07H 19/167
Applicants: GILEAD SCIENCES INC
Inventors: ZABLOCKI JEFF
ELZEIN ELFATIH
Priority Data: 07763545 02.02.2007 EP
76511406 03.02.2006 US
80185706 18.05.2006 US
Title: (DE) Verfahren zur Herstellung eines A2A-Adenosin-Rezeptor-Agonisten und seiner Polymorphe
(EN) Process for preparing an A2A-adenosine receptor agonist and its polymorphs
(FR) Procédé de préparation d'un agoniste du récepteur A2A-adénosine et ses polymorphes
Abstract: front page image
(EN) Disclosed is a synthesis suitable for large scale manufacture of an A2A- adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph.
Also published as:
NO20083395MXMX/a/2008/009879IL193153EP1989214ZA2008/06666JP2009525347
RU0002447081CN101379073CA2640089KR1020130130868NZ570239ES2593028
AU2007212542IL252700WO/2007/092372