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123. (EP2566867) PYRAZOLE COMPOUNDS AS JAK INHIBITORS

Pub. No.:    2566867    International Application No.:    11714581
Publication Date: Thu Mar 14 00:59:59 CET 2013 International Filing Date: Tue Apr 19 01:59:59 CEST 2011
IPC: C07D 487/04
A61K 31/519
A61P 29/00
A61P 35/00
Applicants: CELLZOME LTD
Inventors: HARRISON RICHARD JOHN
OXENFORD SALLY
HOBSON ANDREW
RAMSDEN NIGEL
MILLER WARREN
Title: PYRAZOLE COMPOUNDS AS JAK INHIBITORS
Abstract:
The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.