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1. EP2531210 - VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION

Office
European Patent Office
Application Number 11702568
Application Date 01.02.2011
Publication Number 2531210
Publication Date 12.12.2012
Publication Kind A1
IPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
CPC
A61K 39/0003
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0003Invertebrate antigens
C07K 14/4354
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43536from worms
4354from nematodes
Applicants US OFFICE OF TECHNOLOGY TRANSFER NAT INST OF HEALTH
UNIV JEFFERSON
Inventors NUTMAN THOMAS B
ABRAHAM DAVID
Designated States
Priority Data 30142610 04.02.2010 US
Title
(DE) IMPFSTOFF UND VERFAHREN ZUR VERWENDUNG GEGEN INFEKTIONEN MIT STRONGYLOIDES STERCORALIS
(EN) VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION
(FR) VACCIN ET MÉTHODES POUR SON UTILISATION CONTRE L'INFÉCTION PAR STRONGYLOIDES STERCORALIS
Abstract
(EN) The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.
(FR) La présente invention concerne un polynucléotide codant pour le gène SSIR du nématode Strongyloides stercoralis, ainsi que le polypeptide codé par le gène SSIR. Il a été observé que lorsque des souris sont immunisées avec le vaccin de polypeptide SSIR, cela confère une immunité aux souris qui ont été implantées avec des implants de Strongyloides stercoralis L3. La présente invention concerne en outre des procédés pour préparer la protéine SSIR, des vecteurs recombinants codant pour le gène SSIR, un vaccin préparé à partir de la protéine SSIR, et des procédés d'utilisation.
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