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1. (EP2526093) REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF

Office : European Patent Office
Application Number: 11735212 Application Date: 21.01.2011
Publication Number: 2526093 Publication Date: 28.11.2012
Publication Kind : B1
Designated States: AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2011021982 ; Publication Number: Click to see the data
IPC:
C07D 239/42
A61K 31/505
A61P 25/00
A61P 35/00
C07C 233/78
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
CPC:
A61K 31/505
A61K 31/164
A61K 31/337
A61K 45/06
C07C 237/36
C07C 259/06
C07D 209/46
C07D 209/48
C07D 213/30
C07D 213/74
C07D 213/81
C07D 235/30
C07D 239/42
C07D 241/20
C07D 263/58
C07D 277/24
C07D 277/82
C07D 401/04
C07D 401/06
C07D 401/12
C07D 403/04
C07D 413/04
C07D 417/06
Applicants: ACETYLON PHARMACEUTICALS INC
Inventors: VAN DUZER JOHN H
MAZITSCHEK RALPH
OGIER WALTER
BRADNER JAMES ELLIOTT
HUANG GUOXIANG
XIE DEJIAN
YU NAN
Priority Data: 2011021982 21.01.2011 US
33646010 22.01.2010 US
Title: (DE) UMGEKEHRTE AMIDVERBINDUNGEN ALS PROTEINDEACETYLASE-HEMMER UND VERWENDUNGSVERFAHREN DAFÜR
(EN) REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
(FR) COMPOSÉS AMIDE INVERSE EN TANT QU'INHIBITEURS DE PROTÉINE DÉSACÉTYLASE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Abstract:
(EN) The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
(FR) La présente invention a pour objet de nouveaux composés « amide inverse » comprenant un groupe chélateur de zinc, et l'utilisation de tels composés dans l'inhibition de HDAC6 et dans le traitement de différentes maladies, de différents troubles ou états pathologiques associés à HDAC6.
Also published as:
RSP-2016/0849IL221056JP2013518050SG182646CA2787756EA201290677
MX2012008553CL2012002026SG10201500444TKR1020120118480CN102933558IL242867
BR112012018246CN105727298CN105753739JP2016153425NZ601655EP3091004
AU2011207289DK2526093ES2592278AU2016213729ID2013/01525PH1/2012/501492
TH151341IN1913/KOLNP/2012PT2526093WO/2011/091213