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1. EP2499159 - COMPOSITIONS, KITS, AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, MONITORING, TREATMENT AND MODULATION OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS AND HYPOXIA ASSOCIATED ANGIOGENESIS DISORDERS USING GALECTIN-1

Office
European Patent Office
Application Number 10830795
Application Date 12.11.2010
Publication Number 2499159
Publication Date 19.09.2012
Publication Kind B1
IPC
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 2317/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
C07K 2317/73
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors ; ; against growth regulators
Applicants DANA FARBER CANCER INST INC
FUND SALES
THE BRIGHAM AND WOMEN'S HOSPITAL INC
CONSEJO NAC DE INVESTIG CIENTÍFICAS Y TECN (CONICET)
Inventors SHIPP MARGARET A
RABINOVICH GABRIEL
OUYANG JING
TAKEYAMA KUNIHIKO
KUTOK JEFFERY L
RODIG SCOTT J
SALATINO MARIANA
RUSSO DIEGO OMAR CROCI
Designated States
Priority Data 26112509 13.11.2009 US
28315909 30.11.2009 US
33577910 12.01.2010 US
Title
(DE) ZUSAMMENSETZUNGEN, KITS UND VERFAHREN ZUR DIAGNOSE, PROGNOSE, ÜBERWACHUNG, BEHANDLUNG UND MODULIERUNG VON AUF TRANSPLANTATIONEN FOLGENDEN LYMPHOPROLIFERATIVEN ERKRANKUNGEN UND HYPOXIEVERMITTELTEN ANGIOGENESEERKRANKUNGEN MITHILFE VON GALECTIN-1
(EN) COMPOSITIONS, KITS, AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, MONITORING, TREATMENT AND MODULATION OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS AND HYPOXIA ASSOCIATED ANGIOGENESIS DISORDERS USING GALECTIN-1
(FR) COMPOSITIONS, KITS ET MÉTHODES UTILISÉS POUR LE DIAGNOSTIC, LE PRONOSTIC, LA SURVEILLANCE, LE TRAITEMENT ET LA MODULATION DES LYMPHOPROLIFÉRATIONS APRÈS GREFFE D'ORGANE ET DE L'HYPOXIE ASSOCIÉE À L'ANGIOGENÈSE AU MOYEN DE LA GALECTINE-1
Abstract
(EN) The present invention is based, in part, on the discovery that galectin-1 (Gall) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and methods for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.
(FR) Cette invention concerne notamment la découverte selon laquelle la galectine-1 (Gal1) joue un rôle dans les lymphoproliférations après greffe d'organe associées aux virus, par exemple les lymphoproliférations associées au VEB et l'hypoxie associée à l'angiogenèse. L'invention concerne des compositions, des kits et des méthodes de diagnostic, de pronostic, de surveillance, de traitement et de modulation des lymphoproliférations associées aux virus, notamment les lymphoproliférations associées au VEB et l'hypoxie associée à l'angiogenèse.