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1. (EP2490718) METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN

Office : European Patent Office
Application Number: 10769133 Application Date: 21.10.2010
Publication Number: 2490718 Publication Date: 29.08.2012
Publication Kind : B1
Designated States: AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2010053600 ; Publication Number: Click to see the data
IPC:
A61K 39/395
A61K 39/00
C07K 16/40
C12Q 1/37
G01N 33/53
G01N 33/68
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
37
involving peptidase or proteinase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
CPC:
C07K 16/40
A61K 2039/505
C07K 2317/76
G01N 33/68
G01N 2333/705
G01N 2333/96433
G01N 2500/02
Applicants: HOFFMANN LA ROCHE
Inventors: GANESAN RAJKUMAR
KIRCHHOFER DANIEL
Priority Data: 2010053600 21.10.2010 US
25399009 22.10.2009 US
Title: (DE) VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULATION DER HEPSIN-AKTIVIERUNG DES MAKROPHAGEN-STIMULIERENDEN PROTEINS
(EN) METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN
(FR) PROCÉDÉS ET COMPOSITIONS POUR MODULER L'ACTIVATION D'HEPSINE D'UNE PROTÉINE DE STIMULATION DE MACROPHAGE
Abstract: front page image
(EN) The invention provides methods and compositions for modulating hepsin activity and the MSP/Ron pathway, in particular by regulating pro-MSP activation by hepsin.
(FR) L'invention concerne des procédés et compositions visant à moduler l'activité d'hepsine et le chemin MSP/Ron, en particulier en régulant l'activation pro-MSP par l'hepsine.
Also published as:
US20120282271JP2013507967CN102711826CA2778442RU2012120863MX2012004617
RU0002539772KR1020120105446ES2564207BR112012009409IN3566/CHENP/2012WO/2011/050194