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1. EP2454280 - SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCER

Office European Patent Office
Application Number 10734415
Application Date 13.07.2010
Publication Number 2454280
Publication Date 23.05.2012
Publication Kind A2
IPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
G01N 33/57415
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57415of breast
C07K 14/4748
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
C07K 16/3015
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
3015Breast
G01N 33/57488
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57484involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
57488involving compounds identifable in body fluids
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 2333/765
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
76Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
765Serum albumin, e.g. HSA
Applicants UNIV TEMPLE
Inventors CHANG FRANK N
DUONG PHU T
TUSZYNSKI GEORGE P
Designated States
Priority Data 2010041813 13.07.2010 US
22525409 14.07.2009 US
67034310 22.01.2010 US
Title
(DE) MIT FRÜHSTADIUM UND ANDEREN STADIEN VON BRUSTKREBS ASSOZIIERTE SERUMMARKER
(EN) SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCER
(FR) MARQUEURS DANS LE SÉRUM ASSOCIÉS À DES STADES PRÉCOCES ET À D'AUTRES STADES D'UN CANCER DU SEIN
Abstract
(EN)
Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided. Electrophoretic separation profiles representing different diseases or different cancer stages can be produced, and used in the diagnosis, prognosis and treatment of these diseases. Methods for identification of a cancer peptide fragment comprising a cancer peptide motif are provided. Also provided are breast cancer and other cancer markers and antibodies that specifically recognize these markers.

(FR)
L'invention porte sur des procédés pour identifier des marqueurs spécifiques d'une maladie, en particulier des marqueurs du cancer du sein, par séparation électrophorétique de complexes d'albumine de sérum dans un échantillon biologique sur une membrane. Les profils de séparation électrophorétique représentant différentes maladies ou différents stades de cancer peuvent être produits et utilisés dans le diagnostic, pronostic et traitement de ces maladies. L'invention porte sur des procédés d'identification d'un fragment peptidique de cancer comprenant un motif peptidique de cancer. L'invention porte également sur des marqueurs du cancer du sein et d'autres cancers et sur des antibiotiques qui reconnaissent spécifiquement ces marqueurs.