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1. (EP2447372) Anti alpha v beta 6 antibodies and uses thereof

Office : European Patent Office
Application Number: 11008296 Application Date: 10.07.2006
Publication Number: 2447372 Publication Date: 02.05.2012
Publication Kind : A8
Designated States: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR
Prior PCT appl.: Application Number:US2006026598 ; Publication Number: Click to see the data
IPC:
C12P 21/08
A61K 39/395
C07H 21/04
C07K 16/00
C12P 21/04
G01N 33/53
G01N 33/574
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
04
Cyclic or bridged peptides or polypeptides, e.g. bacitracin
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
CPC:
A61K 2039/505
A61K 2039/545
C07K 16/2839
C07K 16/30
C07K 2317/24
C07K 2317/41
C07K 2317/567
C07K 2317/76
C07K 2317/77
G01N 33/57407
G01N 33/57492
G01N 33/6893
G01N 2333/70546
G01N 2800/085
G01N 2800/12
G01N 2800/20
G01N 2800/347
Y10S 424/80
Y10S 424/801
Applicants: BIOGEN IDEC INC
Inventors: VIOLETTE SHEILA M
KOOPMAN LOUISE A
SIMON KENNETH J
WEINREB PAUL H
VAN VLIJMEN HERMAN
SALDANHA JOSE
LUGUVSKOY ALEXEY A
Priority Data: 06774580 10.07.2006 EP
69744205 08.07.2005 US
77331006 15.02.2006 US
Title: (DE) Anti-Alpha-V-Beta-6-Antikörper und Verwendungen dafür
(EN) Anti alpha v beta 6 antibodies and uses thereof
(FR) Anticorps anti-alpha v bêta 6 et utilisations associées
Abstract: front page image
(EN) The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin ±v²6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin ±v²6.
(FR) L'invention se rapporte aux domaines de la biologie cellulaire, de l'immunologie et de l'oncologie. Spécifiquement, l'invention concerne des anticorps humanisés reconnaissant des intégrines v 6, comprenant une région variable, d'origine non humaine, et au moins une portion d'une immunoglobuline d'origine humaine. L'invention concerne également des procédés pour leur préparation, des compositions pharmaceutiques les renfermant, ainsi que des procédés de traitement de diverses maladies par administration d'anticorps humanisés anti-v 6. L'invention concerne en outre l'identification de l'expression différentielle de l'intégrine av$g(b)6 sur les surfaces de cellules et de tissus tumoraux, l'utilisation de cette expression différentielle dans la détermination du potentiel métastatique des cellules tumorales, et des procédés de diagnostic et de traitement/prévention des métastases tumorales et de l'élimination des cellules tumorales métastatiques résiduelles au moyen de ligands, en particulier d'anticorps se liant à l'intégrine av$g(b)6.
Also published as:
KR1020080031049BRPI0612778EP1920065EP2458012EP2458013CN101287841
CA2614183EA200800278KR1020130042636KR1020140068200AU2006269266IN1140/DELNP/2008
ES2700025WO/2007/008712