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1. (EP2431461) Lipase congeners with enhanced substrate access

Office : European Patent Office (EPO)
Application Number: 10177742 Application Date: 20.09.2010
Publication Number: 2431461 Publication Date: 21.03.2012
Publication Kind : A1
IPC:
C12N 9/20
C11D 3/386
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
18
Carboxylic ester hydrolases
20
Triglyceride splitting, e.g. by means of lipase
C CHEMISTRY; METALLURGY
11
ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
D
DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3
Other compounding ingredients of detergent compositions covered in group C11D1/101
16
Organic compounds
38
Products with no well-defined composition
386
Preparations containing enzymes
CPC:
C11D 3/38627
C12N 9/20
C12Y 301/01003
Applicants: UNIV HAMBURG HARBURG TECH
TUTECH INNOVATION GMBH
Inventors: BUDISA NEDILJKO
WILTSCHI BIRGIT
ROYTER MARINA
ANTRANIKIAN GARABED
GROTE RALF
Priority Data: 10177742 20.09.2010 EP
Title: (DE) Lipase-Congenere mit erhöhter Substratzugänglichkeit
(EN) Lipase congeners with enhanced substrate access
(FR) Congénères de lipase avec accès de substrat amélioré
Abstract: front page image
(EN) The present invention relates to the field of enzyme optimization, and in particular to the optimization of lipase enzymes. Specifically, the invention provides a lipase enzyme which has been modified by the incorporation of one or more non-canonical amino acids to give a lipase congener, said lipase congener having an increased enzymatic activity in an aqueous phase compared to the unmodified enzyme. The invention also relates to the use of such lipase congeners in the soap and detergent industry.