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1. EP4036078 - CRYSTALLINE FORM OF CAPSID PROTEIN ASSEMBLY INHIBITOR CONTAINING N HETERO FIVE-MEMBERED RING, AND APPLICATION THEREOF

Office
European Patent Office
Application Number 20868151
Application Date 28.09.2020
Publication Number 4036078
Publication Date 03.08.2022
Publication Kind A1
IPC
C07D 207/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
A61K 31/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07D 207/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
Applicants CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD
Inventors LU YIN
GUO MENG
HU MINGTONG
LI YUAN
AO WANGWEI
ZHANG YINSHENG
Designated States
Priority Data 201910934549 29.09.2019 CN
Title
(DE) KRISTALLINE FORM EINES KAPSIDPROTEINASSEMBLIERUNGSINHIBITORS MIT EINEM HETEROFÜNFGLIEDRIGEN RING UND VERWENDUNG DAVON
(EN) CRYSTALLINE FORM OF CAPSID PROTEIN ASSEMBLY INHIBITOR CONTAINING N HETERO FIVE-MEMBERED RING, AND APPLICATION THEREOF
(FR) FORME CRISTALLINE D'UN INHIBITEUR DE L'ASSEMBLAGE DE LA PROTÉINE DE CAPSIDE COMPORTANT UN CYCLE À CINQ CHAÎNONS AVEC N COMME HÉTÉROATOME, ET SON APPLICATION
Abstract
(EN) Disclosed by the present application is a crystalline form of a capsid protein assembly inhibitor containing an N hetero five-membered ring; specifically disclosed is the crystalline form of the compound of formula I; also comprised is an the application of said crystalline form in the preparation of a drug for preventing or treating diseases benefiting from the inhibition of capsid protein assembly.
(FR) La présente invention concerne une forme cristalline d'un inhibiteur de l'assemblage de la protéine de capside comportant un cycle à cinq chaînons avec N comme hétéroatome. Plus précisément, l'invention concerne la forme cristalline du composé représenté par la formule I. L'invention concerne également l'application de ladite forme cristalline dans la préparation d'un médicament pour la prévention ou le traitement de maladies tirant bénéfice de l'inhibition de l'assemblage de la protéine de capside.