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1. EP3936856 - CIRCUIT AND METHOD FOR FLUORESCENCE LIFETIME IMAGING

Office
European Patent Office
Application Number 20185370
Application Date 10.07.2020
Publication Number 3936856
Publication Date 12.01.2022
Publication Kind A1
IPC
G01J 3/44
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry
G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 21/6408
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6408with measurement of decay time, time resolved fluorescence
G01N 21/6456
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
G01N 2201/123
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
12Circuits of general importance; Signal processing
123Conversion circuit
Applicants UNIV BRUSSEL VRIJE
Inventors KUIJK MAARTEN
INGELBERTS HANS
Designated States
Priority Data 20185370 10.07.2020 EP
Title
(DE) SCHALTUNG UND VERFAHREN ZUR FLUORESZENZLEBENSDAUERABBILDUNG
(EN) CIRCUIT AND METHOD FOR FLUORESCENCE LIFETIME IMAGING
(FR) CIRCUIT ET PROCÉDÉ POUR IMAGERIE DE DURÉE DE VIE DE FLUORESCENCE
Abstract
(EN) A detector (500, 600, 900, 1200) for detecting fluorescence lifetime comprises a single-photon detection circuit (150) for generating digital pulses upon detection of photons; a pulse-inhibit circuit (165, 166) for rejecting detected photons that occur outside a measurement window; and a switched-capacitor circuit (160) for computing, based on the center of mass principle and an exponential moving average function, an average voltage dependent on the fluorescence lifetime determined by the detected and not rejected photons, wherein the switched-capacitor circuit has an output node (172) for outputting the computed average voltage as a measure of the fluorescence lifetime.
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