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1. EP3932866 - NANOPARTICLE WITH A BUFFER LAYER

Office
European Patent Office
Application Number 20184045
Application Date 03.07.2020
Publication Number 3932866
Publication Date 05.01.2022
Publication Kind A1
IPC
C01F 17/30
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
FCOMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE EARTH METALS
17Compounds of rare earth metals
30Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 40/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
40Manufacture or treatment of nanostructures
CPC
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 40/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
40Manufacture or treatment of nanostructures
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C01F 17/36
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
FCOMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
17Compounds of rare earth metals
30Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6
36halogen being the only anion, e.g. NaYF4
C01P 2004/04
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
2004Particle morphology
01depicted by an image
04obtained by TEM, STEM, STM or AFM
C01P 2002/72
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
2002Crystal-structural characteristics
70defined by measured X-ray, neutron or electron diffraction data
72by d-values or two theta-values, e.g. as X-ray diagram
Applicants UNIV AMSTERDAM
Inventors ZHANG HONG
FENG YANSONG
Designated States
Priority Data 20184045 03.07.2020 EP
Title
(DE) NANOPARTIKEL MIT EINER PUFFERSCHICHT
(EN) NANOPARTICLE WITH A BUFFER LAYER
(FR) NANOPARTICULE DOTÉE D'UNE COUCHE TAMPON
Abstract
(EN) In accordance with the present invention there is provided a nanoparticle, comprising- a core,- an outer layer, and- a buffer layer located between said core and said outer layer,wherein the buffer layer prevents energy transfer between the core and the outer layer.In another aspect of the invention there is provided a nanoparticle as described herein for use in therapy, a nanoparticle according as described herein for use in treatment of a tumor, and a nanoparticle as used herein for use in in vivo imaging.According to another aspect of the invention there is provided a method for the production of a nanoparticle as described herein, comprising the steps of- heating of a solution comprising core precursors, followed by- injection of a dispersion comprising buffer layer precursors, followed by- injection of a dispersion comprising outer layer precursors.Another aspect of the invention is a method for in vivo imaging or treatment or both of a human or animal, comprising the steps of:- administering nanoparticles as described herein to a patient,- irradiating at least part of the patient's body with one or more types of radiation.According to yet another aspect of the invention there is provided the use of a nanoparticle as described herein for therapy, in vivo imaging, or both.
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