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1. EP3911343 - METHODS OF PURIFYING AN ALLERGEN EXTRACT

Office
European Patent Office
Application Number 19713033
Application Date 26.03.2019
Publication Number 3911343
Publication Date 24.11.2021
Publication Kind A1
IPC
A61K 35/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues 
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 35/646
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
63Arthropods
646Arachnids, e.g. spiders, scorpions, ticks or mites
CPC
A61K 35/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 35/646
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
63Arthropods
646Arachnids, e.g. spiders, scorpions, ticks or mites
A61K 35/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
68Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
Applicants LETI PHARMA S L
Inventors ROMÁN-ESCUTIA MARTA
MORALES MARÍA
GALLEGO MARÍA TERESA
CARNÉS SÁNCHEZ JERÓNIMO
Designated States
Priority Data 19382030 17.01.2019 EP
Title
(DE) VERFAHREN ZUR REINIGUNG EINES ALLERGENEXTRAKTES
(EN) METHODS OF PURIFYING AN ALLERGEN EXTRACT
(FR) PROCÉDÉS DE PURIFICATION D'EXTRAITS D'ALLERGÈNES
Abstract
(EN) The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.
(FR) L'invention concerne des procédés de production d'extraits d'allergènes semi-purifiés et purifiés ainsi que des compositions pharmaceutiques et des vaccins destinés à être utilisés dans le diagnostic et le traitement d'allergies. Dans un aspect de l'invention, l'invention concerne un procédé de production d'un extrait d'allergène dépigmenté, le procédé comprenant les étapes suivantes consistant : a) à rendre basique un extrait d'allergène natif ; et b) à éliminer les molécules de poids moléculaire inférieur à 3,5 kDa ; et c) à ajuster le pH à la neutralité ; permettant ainsi la production d'un extrait d'allergène dépigmenté.
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