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1. EP3903831 - MAGNETIC RESONANCE IMAGING DRUG CONTAINING A DEUTERATED NATURAL BRANCHED-CHAIN AMINO ACID, AND DIAGNOSTIC METHOD USING SAID DRUG

Office
European Patent Office
Application Number 19901524
Application Date 08.05.2019
Publication Number 3903831
Publication Date 03.11.2021
Publication Kind A1
IPC
A61K 49/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
10Organic compounds
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
055involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
CPC
A61K 49/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
Applicants SOLVEX LLC
Inventors LESIV ALEKSEI VALEREVICH
IVASHKIN PAVEL EVGENEVICH
KOSENKOV ALEKSEI VIKTOROVICH
POLSHAKOV VLADIMIR IVANOVICH
KISELEVSKII MIKHAIL VALENTINOVICH
KOROL' BORIS NATANOVICH
Designated States
Priority Data 2018147615 29.12.2018 RU
Title
(DE) ARZNEIMITTEL FÜR MAGNETRESONANZBILDGEBUNG MIT EINER DEUTERIERTEN NATÜRLICHEN VERZWEIGTKETTIGEN AMINOSÄURE UND DIAGNOSTISCHES VERFAHREN UNTER VERWENDUNG DES BESAGTEN ARZNEIMITTELS
(EN) MAGNETIC RESONANCE IMAGING DRUG CONTAINING A DEUTERATED NATURAL BRANCHED-CHAIN AMINO ACID, AND DIAGNOSTIC METHOD USING SAID DRUG
(FR) PRÉPARATION POUR IMAGERIE PAR RÉSONANCE MAGNÉTIQUE ET/OU D'UNE SPECTROSCOPIE PAR RÉSONANCE MAGNÉTIQUE CONTENANT UN ACIDE AMINÉ NATUREL DEUTÉRIÉ AVEC CHAÎNE LATÉRALE RAMIFIÉE ET PROCÉDÉ DIAGNOSTIQUE UTILISANT CETTE PRÉPARATION
Abstract
(EN) The invention relates to the means for magnetic resonance imaging of oncological diseases and other diseases, accompanied by a locally altered level of absorption of nutrients by cells. The invention is the diagnostic drug containing at least one deuterated derivative of a natural branched-chain amino acid, as well as the diagnostic method based on the use of this diagnostic drug. The method of the invention includes performing magnetic resonance imaging and / or deuterium magnetic resonance spectroscopy after administration of the diagnostic drug in a time sufficient for the accumulation of the diagnostic drug in a target area of a subject's body. The proposed method allows to carry out a highly informative diagnostics of oncological diseases and other diseases, accompanied by a locally altered level of absorption of nutrients by cells.
(FR) L'invention concerne des moyens de diagnostic par résonance magnétique de maladies oncologiques ou d'autres maladies présentant un niveau d'absorption localement modifié de nutriments par les cellules. L'invention porte sur une préparation diagnostique contenant au moins un dérivé deuteuré d'acide aminé naturel avec une chaîne latérale ramifiée et procédé diagnostique basé sur l'utilisation de cette préparation diagnostique. La méthode de l'invention comprend la réalisation d'une imagerie par résonance magnétique et/ou d'une spectroscopie par résonance magnétique sur les noyaux de deutérium après l’injection de la préparation diagnostique suivant un temps suffisant pour l’accumulation de la préparation diagnostique dans le tissu tumoral du sujet. La méthode proposée permet de diagnostiquer avec une valeur informationnelle élevée le cancer ou d'autres maladies présentant un niveau localement modifié d'absorption de nutriments par les cellules.
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