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1. EP3852752 - SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF

Office
European Patent Office
Application Number 19780127
Application Date 19.09.2019
Publication Number 3852752
Publication Date 28.07.2021
Publication Kind A1
IPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants HOFFMANN LA ROCHE
Inventors MALHOTRA SUSHANT
STIVALA CRAIG
WEI BINQING
CHAN BRYAN K
HEFFRON TIMOTHY
LAINCHBURY MICHAEL
MADIN ANDREW
PANCHAL TERRY AARON
SEWARD EILEEN MARY
BLENCH TOBY
CARTWRIGHT MATTHEW W
DECHAUX ELSA AMANDINE
ELLIOTT RICHARD
GANCIA EMANUELA
Designated States
Priority Data 2018106536 19.09.2018 CN
Title
(DE) SPIROCYCLISCHE 2,3-DIHYDRO-7-AZAINDOL-VERBINDUNGEN UND VERWENDUNGEN DAVON
(EN) SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS 2,3-DIHYDRO-7-AZAINDOLE SPIROCYCLIQUES ET LEURS UTILISATIONS
Abstract
(EN) Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I), variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
(FR) L'invention concerne des composés 2,3-dihydro-7-azaindole spirocycliques de formule (I), leurs variantes et leur utilisation en tant qu'inhibiteurs de HPK1 (kinase hématopoïétique 1). Les composés sont utiles dans le traitement de troubles dépendant de HPK1 et l'amélioration d'une réponse immunitaire. L'invention concerne également des procédés d'inhibition de HPK1, des procédés de traitement de troubles dépendant de HPK1, des procédés d'amélioration d'une réponse immunitaire, et des procédés de préparation des composés 2,3-dihydro-7-azaindole spirocycliques.
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